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This looks good so far. I have noticed that you guys are going to be referencing your sources (which is needed) and there is a referencing style that is useful for wikidot that allows the site to build your bibliography numbers automatically for you so that you don't have to do it manually. Its pretty easy syntax tat you can find in the how to pages. I recommend that you start on this now and do it with each thing you load up on the page or it is going to be massively tedious and time consuming at the end.
Also, the introduction is good but it is based on a school text book. 99% of things that are loaded on this page needs to come from primary research. Text books are usually out of date by the time they are printed and don't offer the most recent evidence, even for something as basic as the intro. Try to find a good review article to make the intro from.
Otherwise looking good so far!
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I know that this page is due soon and I wanted to give you some feedback regarding the content of your page. I really like the table of cellular components, it organizes it very well. However, the depth of knowledge is lacking. Just going by your list of references, you guys as a group need to go deeper into the pathways and cell bio of cellular components. One thing that I noticed that is a HUGE gap in your content is the lack of information regarding the inflammatory processes of PD. This is a MASSIVE component of the disease and I don't see anything about it. I don't know if this is because you haven't uploaded it yet or if its because it wasn't touched on. I know that there are tons of research out there on this w/human and animal models so I expected to see more content in this. Please rectify this before the due date or this might be reflected in your grade.
I think this page is well done and very easy to follow. I appreciated the flow between sections and summary statements.I liked your introduction and think that it set up the page nicely. I would however, remove the sentence about rehab and move that to your exercise page. Also, I'm not sure you should include the level of detail about clinical manifestations and disease progression on the cell bio page. Need to change "a-synuclein" to alpha or the alpha symbol.
In undergrad I was in a neuroscience course where we spent half the quarter learning about the cellular mechanisms of Parkinson's disease. So I have comments about some things that I was missing on your page.
First, I think you made a big omission regarding the animal models. After the MPTP drug was discovered to cause Parkinson's like symptoms the very first animal model for PD was created, which was rats. This is the classical animal model for this disease. Mice were not first as your page leads me to believe. The rats were treated with reserpine to model the disease.
I think your page would benefit from describing the D1 and D2 pathways in the presence and absence of dopamine, in its own section,not buried within a section and paragraph. You only touched on it, I think it should have more detail—which is important in understanding exercise effects and symptom presentation.
I was also missing neuromelanin and it's relationship with oxidative stress.
I didn't see overt mention of the Ubiquitin-proteosome system and it's relationship to Parkin—if you don't have Parkin you have a lot of misfolded proteins which is toxic to the cell.
I think it should also be mentioned that symptoms of PD don't appear until about 85% of DA is lost and the mechanisms underlying why this is—this is a big problem in the effective treatment and prevention of the disease. Some of the mechanisms include presynaptic compensatory mechanisms (such as pumping out more neurotransmitters-increased release of DA, increased turnover (breakdown), decreased DA reuptake (keep in the synapse for longer periods of time)) and post-synaptic compensatory mechanisms such as increasing the affinity of receptors for dopamine, increasing number of receptors and increasing the sensitivity of second messenger systems to dopamine. All these mechanisms contribute to why it takes 85% loss of DA before you see the first tremor.
Hope some of this is helpful for your page!
You may also want to look at medium spiny neuron and NMDA receptors involvement.
The overall organization and flow of the page is great. It is easy to understand the information presented. I only have a couple comments. In the inflammation section, near the end it has TGF-beta. Consider adding the β symbol instead of the word beta. Also, I agree with Cara that you may consider condensing the amount of clinical manifestation information about PD.
The overall organization and flow of the page is great. It is easy to understand the information presented. I only have a couple comments. In the inflammation section, near the end it has TGF-beta. Consider adding the [β] symbol instead of the word beta. Also, I agree with Cara that you may consider condensing the amount of clinical manifestation information about PD.
The page is nicely organized. I especially appreciate the breakdown of the cell bio components because it makes it easy to read and gives clear definitions of each. I found that to be difficult with several of our topics as many overlapped. So I think that's great! I'm not sure, but you may think about putting the interventions with the exercise page.
The page is nicely organized. I especially appreciate how the cell bio components are divided up, because it is easy to read and provides clear definitions of each. I know it was difficult to do that with several of our topics as many overlapped. So I think that's great! I'm not sure, but you may want to consider putting the interventions on the exercise page.